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If at some point the beta cells fail to release enough insulin to control glucose levels.
當到達了某一個臨界點時β細胞無法釋放出足夠的胰島素去控制葡萄糖水平時
That's the beginning of diabetes called pre-diabetes and then it evolves to diabetes.
糖尿病就發生了我們稱之為"前糖尿病"它可能發展成為糖尿病
And so in fact insulin sensitivity and the beta cell response have to be compensating for each other.
所以事實上胰島素敏感性和β細胞的反應是互補的
And remain...and the product of the two which is the disposition index has to remain constant so if for some reason.
而作為兩者平衡的結果就是葡萄糖穩態指數應該保持恒定如果出于某種原因
You become less insulin sensitive like a women becomes pregnant or you are taking a drug.
你的胰島素敏感性降低了比如懷孕婦女或者你正在服用某種藥物
Or you put on some weight as long as your beta cells are able to up regulate the production of insulin.
或者你的體重增加了那么只要你的β細胞能夠向上調整胰島素的分泌水平
Your diabetes risk will not change but if in fact your beta cells cannot accommodate that extra load.
那么你患糖尿病的風險將不會出現變化但如果事實上你的β細胞不堪重負
Then this hyperbola will move to the origin and your diabetes risk will be increased so in this first study of Dr. Spiegel.
那么這條拋物線將會回到最初的位置你患糖尿病的風險便增加了在斯彼格博士的第一項研究中
She noticed a decrease of insulin sensitivity with sleep loss 5 days of 4 hours in bed However, the beta cells instead of compensating.
她注意到睡眠缺失會造成胰島素敏感度的下降也就是連續5天 每天只睡4個小時然而 β細胞不僅沒有釋放出更多的胰島素
And releasing more they actually release significantly less and therefore, the disposition index.
去進行彌補釋放出的胰島素反而大幅度減少了因此 葡萄糖穩態指數
This marker of diabetes risk inversely related to diabetes risk so the lower the disposition index.
也就是糖尿病風險的標識與糖尿病風險成反比葡萄糖穩態指數越低
The higher the diabetes risk was significantly changed Three years after that.
糖尿病風險越大因此這些人的葡萄糖穩態指數發生了顯著變化三年之后
Nedeltchava team did another study where those were overweight, mid-age individuals 14 nights of 5.5 hours in bed is compared.
內德爾查韋研究團隊開展了另一項研究研究對象是體重超重的中年人比較他們在連續14天每晚只睡5.5個小時的狀態
