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To a full rested condition decreased insulin sensitivity beta cells failing again to compensate.
和充分休息的狀態發現他們的胰島素敏感性也降低了而β細胞也沒有進行彌補
And therefore, decrease in disposition index Two years ago Dr. Buxton now at Harvard.
因此他們的葡萄糖穩態指數也下降了兩年前現任哈佛大學教授的巴克斯頓博士
Published this other study 6 nights of 5-hour bedtimes in healthy young individuals decrease of insulin sensitivity.
發表了另一項研究他讓健康的年輕人連續6夜每晚只睡5個小時結果他們的胰島素敏感度也下降了
No compensation by the beta cells and therefore, decrease in diabetes risk and that could put few more of these studies on this slide.
而β細胞沒有做出彌補因此他們的糖尿病風險增加了我還可以列舉出很多類似的研究
Just to show you that there is a good consistency in these laboratory studies that all two people who were.
我只是想向大家說明實驗室研究結論是一致的也就是說
totally with normal glucose tolerance at baseline and who became pre-diabetic after the sleep manipulation now this is to share with you.
原本葡萄糖耐受力正常的人睡眠受到干擾后 都出現了前糖尿病癥狀我想和大家分享這個信息
We were interested to figure out this insulin sensitivity this decline in insulin sensitivity can we measure it at the molecular level.
我們很想搞清楚胰島素敏感度是多少胰島素敏感度下降了多少是否可以在分子層面對其進行測試
So one tissue that can be easily sampled in healthy humans is adipose tissue it’s not difficult to take a biopsy of fat around the umbilicus.
健康人體中最容易獲得的樣本就是脂肪組織了從肚臍周圍取一些脂肪組織進行活檢并不困難
And we asked the volunteers whether they would accept this procedure and have it both with normal sleep.
我們問志愿者是否接受這個小手術在正常睡眠情況下做一次
And then a month later with restricted sleep this was really a collaboration led by the adipocyte biologist Hermann Grady.
然后在一個月的睡眠限制后在做一次這項工作的領導者是脂肪細胞生物學家愛爾曼格拉迪
And what we measured... Then the fat cells are isolated and what we measured in the fat cells.
我們測量了什么呢我們將脂肪細胞進行分離我們在脂肪細胞中的測量內容
Is one of the first steps of insulin signaling so insulin...this is the cell membrane this is the inside of adipocyte.
就是胰島素發出信號過程的第一步這是細胞膜這是脂肪細胞內部
