評論
打印
So we're not gonna talk about eating behavior
我不打算講飲食行為
I'm not gonna talk about obesity-related disease
不打算講與肥胖相關(guān)的疾病
With the focus on inflammation
而只關(guān)注炎癥
Because I actually think
因為我確實認為
This is one of the central mechanisms
炎癥是一種核心的機制
Through which these factors impact obesity-related disease
通過發(fā)炎 這些因素誘發(fā)了與肥胖相關(guān)的疾病
So a little bit of information for those
所以如果在座各位對這方面不熟悉
Who are unfamiliar
我稍微給大家講講
Necessary for survival
對于生物的生存來說至關(guān)重要
It's mediated by proteins
產(chǎn)生炎癥的中介是一種蛋白質(zhì)
Known as pro-inflammatory cytokines
也就是人們已知的前炎性細胞因子
Or other proteins that are produced by immune cells and fat cells
或者由免疫細胞或脂肪細胞產(chǎn)生的其他蛋白質(zhì)
As I mentioned necessary for survival
我剛才提到 炎癥對于生存至關(guān)重要
They orchestrate the immune system
炎癥激發(fā)了免疫系統(tǒng)
They orchestrate communication between cells
指揮細胞間的信息傳遞
And throughout the immune system
這種信息傳遞遍布整個免疫系統(tǒng)
In particular integral in wound healing
在傷口愈合過程中不可或缺
But at chronic levels
但是長期來看
Inflammation has been predictive epidemiologically in laboratory base studies towards disease outcomes
從流行病學(xué)的角度看實驗室研究證明 炎癥會最終誘發(fā)疾病
Particularly cardiovascular disease for instance
特別是誘發(fā)心血管疾病
But getting back to how it's related to obesity as I mentioned
但是回到我剛才提到的炎癥與肥胖癥的關(guān)系
You get this macrophage migration
巨噬細胞會四處遷移
And this is one of the key sources of inflammatory cytokines
這是炎性因子關(guān)鍵的來源
So as the adipose grows
隨著脂肪的增加
More cells migrate into this area
有更多的細胞遷移到這個區(qū)域
Leading to crosstalk between macrophages and adipocytes
使巨噬細胞和脂肪細胞之間發(fā)生信息交流
Adipocytes begin to release pro-inflammatory cytokines
于是脂肪細胞釋放出前炎性因子
As well as macrophages there
和巨噬細胞
So when you get obese tissue
所以當(dāng)你出現(xiàn)了脂肪組織
You begin to get more and more inflammation
那么你的炎癥就變得越來越厲害
Again the link through between obesity and obesity-related disease
這就是肥胖和肥胖相關(guān)的疾病之間的聯(lián)系
So for the data illustration here
依據(jù)這里演示的數(shù)據(jù)
