I ask the question
我提出一個問題
Or there's an emerging evidence
有越來越多的證據(jù)顯示
That poor sleep is associated
睡眠不好會使人們
With increased reactivity to stress exposure
對壓力的反應(yīng)力增強
I want to look first
我首先要研究的問題是
Whether poor sleep affects stress-induced inflammation
睡眠不好是否會影響壓力導(dǎo)致的炎癥
So in response to acute stressor
為了應(yīng)對短期壓力
Whether poor sleep modulates those levels in circulating blood
睡眠不好是否會調(diào)節(jié)血壓循環(huán)
When we are looking at pro-inflammatory cytokine
我們測量了前炎性因子的水平
Specifically IL-6
特別是IL-6的水平
One of the central ones that we measure in humans typically
這是我們測量人體時選擇的主要指標(biāo)
As well as the ratio of IL-6 to IL-10
我們還計算了IL-6和IL-10的比例
And then whether adiposity matters
研究肥胖癥是否嚴(yán)重
You know, I just talked about
我剛才談到了
How this migration seems to be important
細(xì)胞遷移為什么非常重要
And so we can look at
所以我們可以研究
Whether this varies as the function about adiposity
這種改變是否屬于脂肪細(xì)胞的功能
I mentioned, you know, to many
我提到了
You might be unfamiliar with this balance
如果你們對這個問題不熟悉
The IL-6 to IL-10 balance
不熟悉IL-6和IL-10之間的平衡關(guān)系
IL-10 is an anti-inflammatory cytokine
那么IL-10是一種抗炎細(xì)胞因子
And has immunoregulatory properties
具有免疫調(diào)節(jié)的作用
To with the function of resolving that inflammation
其功能是消除炎癥
On kind of as checks of balances system
所以IL-10能夠保持平衡
So the ratio of IL-6 to IL-10
因此IL-6與IL-10的比例
Is thought estimate of pro-inflammatory bias
被認(rèn)為用來判斷炎癥的程度
So the higher the ratio
這個比例越高
Potentially the worse off you are
就你的炎癥系統(tǒng)來說
As far as your inflammation system
你的狀況就越糟糕
But it has previously been shown
但前面已經(jīng)證明
To be responsive to acute laboratory stress
炎癥系統(tǒng)會對短期的實驗室壓力做出反應(yīng)
And so that's why it is included here
所以我們這里也把這個結(jié)果包括了進來
The study was 48 postmenopausal women
這項研究對48名絕經(jīng)后婦女進行了研究