評論
打印
even before the onset of menopause
出現(xiàn)的睡眠問題
So when we look at hot flushes and sleep
我們開始注意到潮熱和睡眠問題
we are back in the 88 when I was in Seattle
是在1988年的西雅圖
We looked at women who were peri-menopausal
我們研究的對象是圍絕經(jīng)期婦女
who had the symptoms and didn't have symptoms
她們有的已經(jīng)出現(xiàn)了癥狀 有的則沒有
In the sleep lab
在睡眠實驗室
there was really very little difference
她們的多導睡眠圖所反映出的客觀數(shù)據(jù)
in their objective polysomnographic sleep
并沒有太大的差別
The difference between wake time of 10% and 13%
分別為10%和13%
is almost nothing
它們之間的差別幾乎可以忽略不計
We've had other people who replicated
有的研究人員不相信我們的研究結(jié)果
that a few years later didn't believe us
他們幾年之后重復了我們的試驗
and then looked at other women flushers and non-flushers
對存在潮熱和沒有潮熱的婦女進行了研究
and there's just only about 5% difference
她們夜間醒來的比例
between their wake time during the night
差別也只有5%
so not enough to explain all the complaints
這個差別不足以說明
about their insomnia during menopause
絕經(jīng)期失眠的原因
Hormone replacement therapy actually
激素替代療法事實上
helped reduce the symptom experience and complaints
能夠降低患者的癥狀
but it had no effect on sleep changes and the stages
但對睡眠各階段的構(gòu)成
or the architecture of sleep
以及睡眠結(jié)構(gòu)沒有任何的影響
Women we did learn from these are CT...
我們從CT上得知
hormone replacement therapy studies was that
激素替代療法研究顯示
there is a very low incidence of periodic limb movements during sleep
這個年齡段的女性
for women in this age group
睡著時的間歇性肢體活動并不多
and a low incidence of sleep disordered breathing
睡眠呼吸障礙的發(fā)生率也不高
we see quite higher incidence of this in man
而男性這種情況比較多
And it is thought that progesterone
人們認為孕酮
was protective of breathing issues for women
可以保護女性不會出現(xiàn)睡眠呼吸障礙
and once menopause hit
但一旦進入絕經(jīng)期
women would have similar rates
女性的睡眠呼吸障礙發(fā)生率
of sleep disorder breathing and sleep apnea
和男性一樣高
but that doesn't seem to be the case
但實際情況并非如此
It's much more associated with obesity
造成睡眠呼吸障礙的原因更多的是肥胖
than with hormones
而不是激素
Freedman and Roehrs in Detroit
來自底特律的弗里曼和羅爾斯
actually didn't believe anybody either
也不相信別人的研究結(jié)果
They did their own study of symptomatic midlife women
他們親自對中年婦女的癥狀進行了研究
and they were scratching their heads after this study
研究結(jié)果也讓他們困惑不已
But they did point out that with very good methodology
但他們確實提供了一種很好的研究方法
women were having about 5 hot flushes during the night
女性每晚平均出現(xiàn)5次潮熱
and they range from 1 to 18
最少1次 最多18次
