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The siRNA is deployed first. It acts for hours, giving enough time to silence and block those survival genes.
siRNA首先開始行動。它需要幾個小時，來讓（癌細胞的）生存基因失效。
We have now disabled those genetic superpowers.
我們去除了（癌細胞的）基因超能力。
What remains is a cancer cell with no special defenses.
只剩下沒有防御的癌細胞。
Then, the chemotherapy drug comes out of the core and destroys the tumor cell cleanly and efficiently.
之后化學藥劑從內核中釋放出來干凈利落地殺死腫瘤細胞。
With sufficient gene blockers, we can address many different kinds of mutations,
只要有足夠多的基因攔截者，我們就能對付各種變異（的癌細胞），
allowing the chance to sweep out tumors, without leaving behind any bad guys.
有機會消滅腫瘤，不留落網之魚。
So, how does our strategy work?
那么，我們的方法到底有沒有效呢？
We've tested these nanostructure particles in animals using a highly aggressive form of triple-negative breast cancer.
我們進行了動物實驗，使用的是一種非常厲害的癌癥，三陰性乳腺癌。
This triple-negative breast cancer exhibits the gene that spits out cancer drug as soon as it is delivered.
它的基因非常厲害，能迅速將抗癌藥排出。
Usually, doxorubicin -- let's call it "dox"
通常，我們會使用阿霉素這種抗癌藥，
is the cancer drug that is the first line of treatment for breast cancer.
它是治療乳腺癌的首選手段。
So, we first treated our animals with a dox core, dox only.
第一次，我們只用阿霉素來對動物進行治療。
The tumor slowed their rate of growth, but they still grew rapidly, doubling in size over a period of two weeks.
腫瘤的增長率有所減緩，但還是增長很快，兩周之內就增長了一倍。
Then, we tried our combination superweapon.
接下來，我們的超級武器上場了。
A nanolayer particle with siRNA against the chemo pump, plus, we have the dox in the core.
外層是siRNA，保護自身不被攔截，內核部分是阿霉素。
And look -- we found that not only did the tumors stop growing,
結果我們發現，腫瘤不但沒有增長，
they actually decreased in size and were eliminated in some cases. The tumors were actually regressing.
而且變小了，在某些樣本上甚至完全消失。腫瘤被擊退了。
