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When the lamin A protein is normally made, a chemical piece called farnesyl is lopped off.
當(dāng)核纖層蛋白A的編碼正常時(shí)，一種名叫法呢基的化學(xué)物質(zhì)會從細(xì)胞核內(nèi)脫落。
In the progeria cell, the farnesyl stays attached. The mutant protein remains sticky and piles up in the nucleus, altering the cell’s function.
而早衰細(xì)胞中的這一化學(xué)物質(zhì)仍然包裹著細(xì)胞核。突變后的蛋白質(zhì)黏著、堆積在細(xì)胞核內(nèi)，改變了細(xì)胞的功能。
Progeria research is moving in two complementary directions.
關(guān)于兒童早衰癥的研究正在向兩個(gè)互補(bǔ)的方向發(fā)展。
Some scientists are working to find treatments for the disease with anti cancer, cholesterol lowering, bone strengthening, and immune suppressing drugs.
一些科學(xué)家嘗試?yán)每拱┧帯⒔抵帯⒔」撬帯⒚庖咭种扑帉ふ抑委熢摷膊〉姆椒ā?/div>
Others are interested in progeria’s similarity to aging.
另一些科學(xué)家則專注于早衰癥與自然老化的相似點(diǎn)。
Progeria like changes have been found in unaffected older people’s skin cells.
一些未患早衰癥的老年人的皮膚細(xì)胞中也出現(xiàn)了類似早衰癥的變化。
A protein called prelamin A, which is similar to the mutant protein, increases at low levels and may contribute to hardening of the arteries and other problems that come with aging.
一種名為前層細(xì)胞A的蛋白質(zhì)與突變后的蛋白質(zhì)相似，其數(shù)量也在緩慢增加，這種蛋白可能會引起動脈硬化及其他老化過程中所出現(xiàn)的問題。
Though progeria is extremely rare, it may in fact hold the key to aging in all individuals.
雖然早衰癥極為罕見，但它可能成為所有人衰老的關(guān)鍵線索。
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