According to a new study from the German Cancer Research Center, deficiencies in vitamin A can be detrimental to blood stem cells.
根據(jù)德國癌癥研究中心的一項新研究,維生素A不足可能對血液干細胞有害。
These specialized cells in the skin, gut, or blood have a relatively short lifespan and require constant replenishment.
皮膚、腸道或血液中的這些特殊細胞的壽命相對較短,需要不斷補充。
In 2008, researchers discovered a group of special stem cells in the bone marrow that remain dormant most of the time
2008年,研究人員在骨髓中發(fā)現(xiàn)了一組特殊的干細胞,這些細胞大部分時間都處于休眠狀態(tài),
and only become active to fight bacterial or viral infections, heavy blood loss or as a reaction to chemotherapy.
只有在對抗細菌或病毒感染,嚴重失血或化療反應(yīng)時變得活躍。
Researchers have now identified the mechanisms that activate and deactivate the stem cells.
研究人員已經(jīng)確定了激活和停用干細胞的機制。
Results showed that retinoic acid, a vitamin A metabolite crucial to the process.
結(jié)果表明維生素A代謝物視黃酸是過程的關(guān)鍵。
Researchers hope the findings will play a role in cancer treatments because cancer cells, like stem cells, rest in a state of dormancy and their metabolism is completely shut down, rendering them resistant to chemotherapy.
研究人員希望這項發(fā)現(xiàn)有助于癌癥治療,因為癌細胞如干細胞處于休眠狀態(tài),代謝作用完全關(guān)閉,致使其抗化療。
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