評論
打印
But within those cells that DNA needs to be functioning all the time
不過在這些細(xì)胞內(nèi)DNA需要一直發(fā)生作用
Not just to make a new cells but to provide the information that is needed
不只是產(chǎn)生新細(xì)胞，還要提供必要的信息
So if I can cartoon this for you
我用卡通示意下
Here's a typical cell
這是典型細(xì)胞
In this case, we pick the macrophage but it could just as well be a breast ductal tissue cell. It doesn't matter
這里還是先那個(gè)巨噬細(xì)胞，也可以是別的什么細(xì)胞，關(guān)系不大
They get some kind of a signal
細(xì)胞會(huì)得到信號
In this case it's a microbe but it could be estrogen circulating in the blood perfectly normal hormones
這里是微生物，當(dāng)然也可以是血液循環(huán)中的雌性激素什么的
Signal but the cell says to itself is that gee, I don't have the equipment I need
這是信號，不過細(xì)胞卻發(fā)現(xiàn)沒有所需要的"設(shè)備"
but then it says, hey, I've got the plans for what I need in my DNA library
此時(shí)細(xì)胞意識(shí)到DNA庫中有相應(yīng)內(nèi)容
And so it takes the signal and transports it into the nucleus where finds the information it needs
于是它將信號送到細(xì)胞核去找需要的信息
And in a matter of minutes, it synthesizes the needed cellular equipment and that constitutes a cell response
幾分鐘后，所需"設(shè)備"得以合成，這就得到細(xì)胞反應(yīng)
This is how we now think of cells
這就是我們現(xiàn)在對細(xì)胞的認(rèn)識(shí)
It turns out that 1,25D is the key that unlocks the DNA library in virtually every tissue in the human body
而1,25D是開啟DNA信息庫的關(guān)鍵，幾乎所有人體組織都是如此
1,25D's synthesized in the cell itself for itself and by itself not dependent upon what's outside the cell
1,25D在細(xì)胞內(nèi)合成，且用于該細(xì)胞，同細(xì)胞外部無關(guān)
It perceives a signal. It says I've got to go and get the information I need in order to respond to this
細(xì)胞接收信號，然后找到應(yīng)答所需要的信息
The only thing I need from the outside is some 25D there so that I can bring it in and make what I need
唯一從外界需要的是25D，將其引入然后進(jìn)行剩下工作
