評論
打印
Dr. Wagner raise this question earlier this afternoon
下午早些時候 Wagner醫生提過的問題
I'm going to raise it again
我準備再次提出
Because it requires that we rethink how a cell works in order to get a clean answer to what's going on here
我們需要明白細胞如何工作才能很好了解這里的情況
How can a single nutrient act in so many different systems and tissues and produce such a wide variety of effects?
這一種營養素如何在這么多系統和組織中工作并產生如此多的效果
So I'm going to step this through in a very oversimplified fashion
我只非常簡單地過一遍
I'm not a cell biologist and so I've had to make a simple enough that I can grasp it
我不是研究細胞生物學的，我只能按我理解的簡單講下
But if there are some cell biologist here and I commit to some degree errors I trust that you to correct me or forgive me or both
如果我犯了錯誤，還請在座的細胞生物學家見諒并歡迎糾正我的錯誤
We start with 1,25D which we recognize now for 30 years
從被研究了30多年的1,25D開始
It's the active end of the vitamin D molecule
它是維生素D分子的活性末端
In the cell, it combine with a protein called the vitamin D receptor
細胞內，它同維生素D受體蛋白結合
And that form is what's called a heterodimer with the retinoid X receptor also binding retinoid
這個形態稱為異源二聚體，再同視黃素X受體結合，該受體還結合視黃素
So vitamin A plays a crucial role in this
維生素A在這里扮演重要角色
and too much or too little can be harmful for how the vit D system works
太多或太少都會對維生素D系統工作產生危害
Now this complex combining with a number of other helper proteins then goes into the nucleus where binds to the genome in vitamin D response elements
復雜的輔助蛋白結合過程后，然后進入細胞核同基因組結合，通過維生素D反應元件
That result in transcription of the information encoded in those genes and the production of a variety of cell constituent proteins
這導致基因內信息編碼的轉錄并產生各種細胞組成蛋白
You saw some of them listed this morning by Cedric Garland
其中一些早上Cedric Garland就列出過
