評論
打印
These are the proteins that are responsible for the control of cell proliferation, cell adhesion, cell differentiation the cell death,
這些蛋白質(zhì)負(fù)責(zé)控制細(xì)胞增殖，細(xì)胞粘附，細(xì)胞分化，細(xì)胞死亡，
various aspects of the immune responseand interestingly, always the production of the 24-hydroxylase
各種免疫反應(yīng)并總合成24-羥化酶，這很有趣
That's the enzyme that breaks down the vitamin D after that, so it's kind of a very quick on off switch
這是一種分解維生素D的酶，它是一種快速"開關(guān)"
as soon as vitamin D exit the genome. It induces an enzyme that destroys it, so it's actually once basically, then it breaks down
維生素D一離開基因組就會產(chǎn)生一種酶來將其破壞，所以只一次就沒了
And then you need more vitamin D molecules if you want to do it again
之后還要繼續(xù)的話，就需要更多維生素D
The striking thing and this number keeps going up from year to year is that over a thousand genes have vitamin D response elements
已發(fā)現(xiàn)超過一千個(gè)基因具有維生素D反應(yīng)元件，這非常令人驚奇，而且數(shù)字還在增長
and some people have estimated as much as 10% of the human genome is dependent upon having adequate vitamin D
有人甚至估計(jì) 10%左右的人類基因組都依賴于適當(dāng)?shù)木S生素D
So it's a terribly important ubiquitous tissue wide issue
可見這非常重要，是無處不在的問題
Now I'm going to step this through in a little bit more detail
這里我再稍微講詳細(xì)一點(diǎn)
Once again we're focusing on 1,25D which one to get into the cell can do what it needs to do
我們還是關(guān)注1,25D進(jìn)入細(xì)胞做它該做的
but we also have recognized that 25D is present in the serum and 25D is not simply a reservoir
不過我們還意識到 25D也在血清中存在，25D不僅僅是一個(gè)"儲藏庫"
It's not simply an index of how much vitamin D we have in the body, although we use it for that and quite appropriately
不僅僅是體內(nèi)維生素D多少的指標(biāo)，當(dāng)然，用它做指標(biāo)確實(shí)很好
25D can be itself 1 alpha hydroxylated within the tissues themselves not just dependant upon what happens inthe kidney
25D本身可以在組織內(nèi)1α-羥基化而不只取決于腎內(nèi)的情況
