評論
打印
So you can see these are the ones
大家可以看到這些老鼠
They are fatter, they are unhealthy mice
這個(gè)老鼠要胖些 屬于不健康的老鼠
And Rawl and Dollman in the commentary for that study
羅爾和道爾曼在對這項(xiàng)研究進(jìn)行評論時(shí)指出
Kind of put it altogether here
放在這里了
So stress leads to glucocorticoids
壓力會導(dǎo)致腎上腺糖皮質(zhì)激素的上升
That can potentiate
而腎上腺糖皮質(zhì)激素又會影響到
The sympathetic neuron and adipose tissue
交感神經(jīng)和脂肪組織
Leading to the release of NPY
從而導(dǎo)致神經(jīng)肽Y抗體水平的上升
And a proliferation of proadipocytes and adipogenesis
從而造成前脂肪細(xì)胞和脂肪形成速度的激增
And macrophage infiltration
造成巨噬細(xì)胞的浸潤
Which is something I'm just highlighting here
這是我想強(qiáng)調(diào)的內(nèi)容
Because it can be relevant to what I talk about towards the end
因?yàn)樗臀易詈笠v的內(nèi)容相關(guān)
Which in turn can end in insulin resistance
這一些列變化反過來導(dǎo)致胰島素抗性的產(chǎn)生
So there is a kind of complicated but verified pathway
所以壓力導(dǎo)致肥胖
With respect to stress and potential biological mechanism to obesity
或者至少導(dǎo)致脂肪細(xì)胞生長的生物過程
Or at least adipose growth
是一個(gè)非常復(fù)雜而多變的過程
But how is sleep involved?
那么睡眠在這中間扮演了什么角色呢?
Again, this is kind of intuitive thing
這又是一個(gè)直覺的問題
I mean we know that individuals who are very high stressed
我們知道承受了巨大壓力的個(gè)體
Stressed in work
例如工作壓力
Have a difficult time sleeping
他們會難以入睡
You know, they don't fall asleep as quickly
他們?nèi)胨臅r(shí)間不夠快
They often can have fragmented sleep
他們的睡眠經(jīng)常被打斷
And less sleep continuity
連續(xù)睡眠的時(shí)間較短
And report that their quality of their sleep was poor
而且他們自述睡眠質(zhì)量不高
In the same way
同樣的
There is some evidence
有證據(jù)證明
That people who don't get enough sleep
睡眠不足的人
Certainly have changes in their mood
可能會出現(xiàn)情緒變化
But there's now an emerging laboratory evidence suggesting
現(xiàn)在有越來越多的試驗(yàn)證據(jù)證明
That individuals are even more sensitive to stress exposure
睡眠不足的個(gè)體對壓力更為敏感
Some of this more comes from
一些證據(jù)來自于
Matt Walker's lab at UC Berkeley
加州伯克利分校的馬特沃克的實(shí)驗(yàn)室
