評論
打印
You can see the beginnings of a kind of J shape here
大家可以看出曲線基本呈現一個J的形狀
but other groups are not significant
但其他人群的情況則不那么顯著
So why this might be the case?
為什么會出現這樣的情況?
So here are some data we presented at APS here
這里是APS的一些數據
the papers and submissions right now
根據會議提交上來的論文
looking at information as potential pathways
這些信息顯示了導致肥胖癥的潛在途徑
So do short and long sleepers
睡眠時間過短和睡眠時間過長
have increased inflammation?
是否會增加炎癥的發生幾率?
So here are some unadjusted and adjusted data
這里有一組NHNES的調整前和調整后的數據
also from NHNES looking at
查看睡眠時間長短
sleep duration categories in CRP
對CRP的影響
which is an important inflammatory marker
CRP是一個重要的炎癥標識物
You can see
大家可以看出
after adjusting for all these typical covariates
在調整了所有典型的協變量
and a couple of new ones
以及一些新的變量之后
that you do have elevation in short and long sleep
短期睡眠和長期睡眠都有了提升
you actually plot it squared turns
這里還出現了直角變化
to actually show a significant U shape
基本上形成了一個顯著的U型
I also do want to know that
我還想知道的是
we included in here variables
我們加入的變量
that could potentially come for insomnia, sleep apnea
對失眠和睡眠呼吸障礙有潛在的影響
So a lot of these population studies looking at sleep duration
所以針對人們睡眠時間的這些研究
are probably confounded by lots of undiagnosed sleep disorders
很可能還涉及到很多未被確診的睡眠障礙
So we try to account for some of that variants there
所以我們也試圖對這些變量進行解釋
So even still we do have elevations there
所以盡管在這里出現了上升趨勢
So there have been a number of studies
但仍然有很多研究
that have looked at this potential pathway
關注的是潛在的致病途徑
Sleep restriction in the laboratory
在實驗室中通過睡眠限制試驗發現
have shown elevations of TNFa and IL-6
TNFa和IL-6都出現了上升
Short sleep duration in the population
樣本人群的睡眠時間短
so this is a little more relevant to the general populations
這樣一般人群中的這些指標
and the stuff we are talking about
都會出現上升趨勢
