評論
打印
The relative risk was calculated versus no supplementation in the same population
他們計算了相對風險對比相同人群中的未補充者
Not everybody of course did what they were
并不是所有人都服用
They were recommended to do under the circumstances
只有被建議的人才會服用
Here the differences are so striking that I have to resort to a log scale once again
差異非常明顯，我必須使用對數刻度才能顯示好
And what we see here is that
這里可以看到
88% lower risk of developing diabetes by age 31 in infants of that 2000 IU per day versus those who got none
每天服用2000IU的嬰兒比沒有服用的在31歲時患糖尿病的風險減少88%
And conversely those whose physicians thought they might have rickets because they had some of the physical symptom
相反，醫生認為可能患有佝僂病的人
They had a three-fold increase in risk over those who just got no vit D in the process
是沒服用維生素D的人的風險的三倍
There's a huge difference between 3-fold and 90% reduction, 2 orders of magnitude
三倍和90%減少之間差異很大，兩個數量級
For reasons which have never been very clear to me that Finnish government backed away from this recommendation
所以我總搞不明白芬蘭政府為何沒遵從這個建議
and now they're down to a recommendation which is similar to that which the American Academy of Pediatrics now has recommended
現在他們采納了一個類似建議由美國兒科學會提議
but I think, this is almost surely what's called an epigenetic effect that is we're changing which genes getexpressed
這應該就是所謂的表觀遺傳現象，我們改變了表達的基因
and that's being programmed very early in life both in embryo and in the first year of life
這在生命早期就已經設定好包括胚胎和一歲前
probably helping the lymphocytes to figure out the difference between self and non self and they don't quiteget it right,
也許幫助淋巴細胞區分自身和非自身，如果沒搞對，
Then you run your increased risk of developing type one diabetes
患1型糖尿病的風險就會增加
Presumably something similar is happening with respect to multiple sclerosis and the other immune disorders
類似的也許還發生在多發性硬化及其它免疫功能紊亂
