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So it's generally associated with reduced total sleep time and we have talked about that already it’s associated with sleep fragmentation.
它通常會導致睡眠時間縮短我們剛才已經談到這個問題了會造成睡眠不連貫
I will discuss that in a minute Low slow-wave activity this was Dr. Tiscali’s experiment.
這是我一會兒要討論的問題慢波活動的降低這是塔莎莉博士的試驗結論
With diabolic sounds coming into the room and then it has intermittent hypoxia which in itself is also deleterious to glucose tolerance.
她在臥室里發出了討厭的聲音然后是間歇性缺氧而這又會損害葡萄糖耐受力
And in this slide I'm just summarizing the findings of three different laboratory studies.
在這個圖表中我對三個不同實驗室的研究結論進行了總結
Two from John Hopkins and Dr. Tiscali’s study where different components of obstructive sleep apnea.
其中兩項試驗是約翰霍普金斯大學以及塔莎莉博士的研究他們在實驗室中
Were mimicked in the laboratory in healthy young subjects so in this study Punjabi and Stamatas’s.
對健康的年輕人模擬了各種睡眠呼吸障礙的情況在這項研究中龐加比和斯坦馬塔奇斯
Induced all stage sleep fragmentation not specific the slow-wave sleep and also showed the reduction of insulin sensitivity.
將睡眠的各個階段都考慮了進來不僅僅是慢波睡眠發現他們的胰島素敏感性都出現了下降
And then, Punjabi and others did a study in the wake subjects but 5 hours of intermittent hypoxia is compared to normoxia.
然后 龐加比和其他人對蘇醒的試驗參與人進行了研究對5個小時的間歇性缺氧和常氧狀態進行了比較
And showing again a decrease of insulin sensitivity I want to just give you a little... You know, these changes.
發現他們的胰島素敏感性出現了下降我給大家看看...變化程度為
Are typical 25% decrease in insulin sensitivity so for normal healthy lean person a 25% decrease of insulin sensitivity?.
胰島素敏感性通常降低了25%所以對于正常的健康的瘦型成年人來說胰島素敏感性每降低25%
Will occur with about a 10-kilo weight gain so it's not a small change it’s a big change.
會讓他們的體重增加10公斤所以這是個不小的變化是個很大的變化
The same team at Hopkins examined then inpatients non-diabetic patients.
霍普金斯大學的同樣的研究團隊對住院病人進行了測試這些病人都不是糖尿病患者
Using this intravenous glucose tolerance test the impact of obstructive sleep apnea on insulin sensitivity so these are cross-sectional laboratory studies.
研究人員用靜脈內葡萄糖耐受力測試方法研究了睡眠障礙對胰島素敏感性的影響這些屬于實驗室進行的橫斷面研究
