評論
打印
How many people here are 40 years old or older? You're afraid to admit it now.
在座的有多少人已經四十多歲了？你不想承認了嗎？
This initial step into the disease, this presence of amyloid plaques accumulating, can already be found in your brains.
老年癡呆癥的起步，淀粉樣斑塊的累積，也許已經在你的大腦初步產生。
The only way we could be sure of this would be through a PET scan, because at this point, you are blissfully unaware.
我們唯一能確認的方式是PET掃描，因為現在你對此毫無知覺。
You're not showing any impairments in memory, language, or cognition ... yet.
你還沒有任何記憶、語言或是認知方面的問題... 現在還沒有。
We think it takes at least 15 to 20 years of amyloid plaque accumulation before it reaches a tipping point,
我們認為淀粉樣斑塊的累積至少需要15至20年時間才會到達它的臨界點，
then triggering a molecular cascade that causes the clinical symptoms of the disease.
隨后引發分子的連鎖反應，導致了這一疾病的臨床癥狀。
Prior to the tipping point, your lapses in memory might include things like,
在這一臨界點之前，你的記憶衰退可能會像這樣：
"Why did I come in this room?" or "Oh ... what's his name?" or "Where did I put my keys?"
“我為什么到這間屋子來？”或是“呃，他叫什么來著？”或是“我把鑰匙放哪了？”
Now, before you all start freaking out again,
現在，在你們驚慌失措之前，
because I know half of you did at least one of those in the last 24 hours -- these are all normal kinds of forgetting.
我知道你們中的半數在過去的24小時內至少有過上述之一，這些都是正常的遺忘類型。
In fact, I would argue that these examples might not even involve your memory,
實際上，我的看法是這些示例，甚至都與你的記憶沒什么關系，
because you didn't pay attention to where you put your keys in the first place.
因為起初你并沒有在意你把鑰匙放在哪里。
After the tipping point, the glitches in memory, language and cognition are different.
在臨界點之后，記憶、語言和認知的偏差是不一樣的。
Instead of eventually finding your keys in your coat pocket or on the table by the door,
最后發現鑰匙并不在你的大衣口袋，或是不在門邊的桌上，
you find them in the refrigerator, or you find them and you think, "What are these for?"
你在冰箱里找到了你的鑰匙，或者你找到鑰匙后想，“這玩意是干嘛的？”
