評(píng)論
打印
As suspected, leptin and melanocortin
一如科學(xué)家的懷疑 瘦蛋白和黑素皮質(zhì)素
are turning out to be just the tip of the iceberg.
只不過是冰山一角
We now know about a number of other
現(xiàn)在我們得知 大腦中的一些其他
chemicals in the brain that act to regulate appetite.
化學(xué)物質(zhì)也在參與食欲調(diào)控過程
We know there are some that act to decrease appetite...
我們也知道 其中一些可以減弱食欲
..Such as the melanocortins, the neuromedins...
比如說黑素皮質(zhì)素 神經(jīng)調(diào)節(jié)肽
..POMC, the melanocortin receptor,
阿片促黑素原 黑素皮質(zhì)素受體
CART...
可卡因-苯丙胺調(diào)節(jié)轉(zhuǎn)錄肽
There are those that decrease appetite,
這些東西都可以降低食欲
such as the orexins, galanin...
例如食欲肽 神經(jīng)節(jié)肽
Neuropeptide Y... There are a number
神經(jīng)肽Y 也有一些
of peptides released from the gut that affect appetite,
內(nèi)臟器官釋放的肽會(huì)影響食欲
such as glucagon-like peptide-1, enterostatin,
例如胰高血糖素樣肽-1 腸抑素
cholecystokinin and on and on and on.
腸促胰酶肽等等
We're expecting more discoveries all the time.
我們一直在期待更多的發(fā)現(xiàn)
But even with all these drug targets,
即使有了所有藥物標(biāo)靶
they still have a long way to go.
前路依然漫漫
In terms of drug treatments for obesity,
在肥胖的藥物治療方面
we're lagging 20 years behind other avenues of research.
與其他研究方向相比 我們落后了20年
We're at the beginning of a long road now and even if a treatment
我們正在漫長(zhǎng)道路的起點(diǎn) 即使明天
were to be identified tomorrow, then we're looking at 10,
就能提出一項(xiàng)治療方法 我們依然
12 years before any treatment is actually available.
要等10年或12年才能真正實(shí)施治療
