故事發生在“蜘蛛俠”打敗“綠色惡魔”的兩年后，彼得·帕克遠離自己摯愛的女友瑪麗·簡，繼續過著平淡而充滿刺激的雙重生活，白天他依舊是溫文爾雅、有些木訥的大學生，晚上則化身成為擁有無限超人力量、除暴安良的蜘蛛俠。不過彼得·帕克卻越來越難以平衡這種雙重性格，周圍的人開始懷疑他的身份，甚至很多人對其開始猜疑和誤解。彼得·帕克一直生活在矛盾中，他希望向瑪麗表白自己的愛戀，更希望能夠跟她坦誠自己的真實身份。另外，彼得發現好友哈里·奧斯本對蜘蛛俠殺了他的父親，一直耿耿于懷，身陷仇恨，不可自拔……

　　與此同時，一場失敗的實驗使一位被稱為“章魚博士”的天才科學家變得偏激和瘋狂，為了奪取權力和錢財，“章魚博士”耍出各種手段，讓他成為令蜘蛛俠最頭疼的敵人。蜘蛛俠為了阻止這位瘋狂科學家的惡行，開始了又一場驚心動魄的冒險之旅……

　　Peter Parker''s having a rough time. His double life as the superhero Spider-Man is having a devastating impact on his civilian life. Things are so bad he declares that he''s quitting, and never putting on the suit again. However, his sense of duty forces him to become a hero again when the brilliant scientist Dr. Otto Octavius is deformed in an accident and becomes Dr. Octopus. With four metal tentacles sticking out of his back, he''ll prove to be a more than worthy opponent for Spider-Man.

　　影片片段：

　　Peter: Now what?

　　Peter: Doctor Octavius. We have to shut it down. Please tell me how.

　　Octavius: Peter Parker! Brilliant but lazy!

　　Peter: Look at what''s happening. We have to destroy it.

　　Octavius: I can''t destroy it. I won''t.

　　Peter: You once spoke to me about intelligence. That was a gift to use for the good of mankind.

　　Octavius: A privilege.

　　Peter: these things have turned you into something you''re not. Don''t listen to them.

　　Octavius: It was my dream.

　　Peter: Sometimes to do what''s right we have to be steady and give up the things you want the most, even our dreams.

　　Octavius: You''re right. He''s right. Listen, listen to me now.

　　Peter: Now, tell me how to stop it.

　　Octavius: It can''t be stopped. It''s self-sustaining now.

　　Peter: Think!

　　Octavius: Unless...the river! Drown it! I''ll do it.

　　Peter: Hi!

　　MJ: Hi.

　　Peter: This is really heavy.

　　Peter: MJ, in case we die...

　　MJ: You do love me.

　　Peter: I do.

　　MJ: Even when you said you didn''t.

　　Octavius: I will not die as a monster.

　　MJ: I think I always know all this time who you really were.

　　Peter: And you know why we can''t be together. Spiderman will always have enemies. I can''t let you take that risk. I will always be spiderman.

　　語言點提示：

　　1. turn someone/something into... 把某人某物變成...

　　someone/something turn into...某人某物變成...

　　例如：Lisa has turned into a beautiful woman.

　　麗莎已經長成一個大姑娘了。

　　2. in case (of...) 萬一...，以防...

　　例如：In case it rains/In case of the rain, you''d better bring an umbrella with you.

　　你最好帶一把傘以防下雨。