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American Society ofClinical Oncology (ASCO)
美國(guó)臨床腫瘤協(xié)會(huì)(ASCO)
New, large cohortanalysis from the prospective Prostate, Lung, Colorectal and Ovarian (PLCO)Cancer Screening Trial, indicates that men who had moderate baldness affectingboth the front and the crown of their head at age 45 were at a 40% increasedrisk of developing aggressive prostate cancer (usually indicates a fastergrowing tumor resulting in poorer prognosis relative to non-aggressive prostatecancer) later in life, compared to men with no baldness. There was nosignificant link between other patterns of baldness and prostate cancer risk.The study, published September 15 inthe Journal of Clinical Oncology, supports earlier research suggesting thatmale pattern baldness and prostate cancer may be linked.
一個(gè)新的，大型的潛在前列腺癌、肺癌、大腸癌和卵巢癌臨床試驗(yàn)篩選斷代分析表明，前額和頭頂頭發(fā)在46歲時(shí)不斷掉落的男性與沒(méi)有脫發(fā)的男性相比，以后患有侵略性前列腺癌的可能性增加40%（通常意味著沒(méi)有很好地診斷出非侵略性前列腺癌而造成的腫瘤的快速擴(kuò)張），而別的部位脫發(fā)則與患前列腺癌的風(fēng)險(xiǎn)沒(méi)有太大的關(guān)聯(lián)。這篇發(fā)表在9月15出版的《臨床腫瘤學(xué)》上的文章證實(shí)了之前的研究結(jié)果，認(rèn)為男性某種類(lèi)型脫發(fā)可能與前列腺癌有關(guān)。
"Our study found anincreased risk for aggressive prostate cancer only in men with a very specificpattern of hair loss, baldness at the front and moderate hair-thinning on thecrown of the head, at the age of 45. But we saw no increased risk for any formof prostate cancer in men with other hair-loss patterns," said seniorstudy author Michael B. Cook, PhD, an investigator in the Division of CancerEpidemiology and Genetics at the National Cancer Institute in Bethesda, MD."While our data show a strong possibility for a link between thedevelopment of baldness and aggressive prostate cancer, it's too soon to applythese findings to patient care."
“我們的研究發(fā)現(xiàn)，只有某些特性類(lèi)型的脫發(fā)，頭前面和頭頂?shù)念^發(fā)在45歲時(shí)開(kāi)始脫落，患侵略性前列腺癌的可能性增加。而其他類(lèi)型的脫發(fā)則與患前列腺癌的風(fēng)險(xiǎn)關(guān)系不大，”位于馬里蘭州貝塞斯達(dá)的美國(guó)國(guó)家癌癥研究所腫瘤流行病學(xué)和遺傳學(xué)部門(mén)的高級(jí)研究員、本文作者邁克爾·b·庫(kù)克博士說(shuō)。“雖然我們的數(shù)據(jù)表明持續(xù)脫發(fā)很可能與侵略性前列腺癌有關(guān)聯(lián)，但將這個(gè)發(fā)現(xiàn)應(yīng)用于病人護(hù)理還為時(shí)尚早。”
Prostate cancer is thesecond most common cancer among men. Emerging evidence suggests that prostatecancer and male pattern baldness -- progressive scalp hair-loss in a distinctpattern -- are both connected to increased levels of male sex hormones(androgens) and androgen receptors, supporting the idea of a biological linkbetween baldness and prostate cancer development and progression.
前列腺癌是男性第二大常見(jiàn)癌癥。新出現(xiàn)的證據(jù)表明前列腺癌和男性某種類(lèi)型的脫發(fā)—以一種特定的模式持續(xù)掉發(fā)—與男性性激素(androgens)和性激素受體的水平增加都有關(guān)聯(lián)，表明脫發(fā)與前列腺癌的發(fā)展和惡化存在著生物關(guān)聯(lián)。
Researchers analyzed malepattern baldness in relation to prostate cancer risk in a cohort of 39,070 menfrom the U.S. PLCO Cancer Screening Trial, aged 55-74 years at enrollment. Themen received a questionnaire that asked them to recall what their hair-losspatterns were at age 45 using a pictorial tool.
研究人員對(duì)進(jìn)行了美國(guó)前列腺癌臨床試驗(yàn)篩選的，登記在冊(cè)的，55到74歲的3萬(wàn)9070名男性進(jìn)行了男性某種類(lèi)型脫發(fā)與患前列腺癌的關(guān)聯(lián)進(jìn)行了分析。這些男性接受了問(wèn)卷調(diào)查，通過(guò)圖形工具回憶他們?cè)?5歲時(shí)的脫發(fā)類(lèi)型。
During follow-up, 1,138prostate cancer cases were diagnosed, 51% of which were aggressive (Gleasonscore equal to or greater than 7, stage III or IV, or prostate cancer as thecause of death). The mean age at the time of prostate cancer diagnosis was 72.
接下來(lái)的隨訪表明，前列腺癌的確診病例的1138例，其中51%為侵略性的（格里森評(píng)分等于或大于7,III期或IV期，或因前列腺癌病死）。診斷出前列腺癌的平均年齡為72歲。
Men who had a specificpattern of baldness, frontal and moderate crown (vertex), were 40% more likelyto develop aggressive prostate cancer, compared to men who had no baldness.There was no association between male pattern baldness and risk ofnon-aggressive prostate cancer.
前額和頭頂頭發(fā)在46歲時(shí)不斷掉落的男性與沒(méi)有脫發(fā)的男性相比，以后患有侵略性前列腺癌的可能性增加40%。而別的部位脫發(fā)則與患前列腺癌的風(fēng)險(xiǎn)沒(méi)有太大的關(guān)聯(lián)
Dr. Cook stated that ifthese findings are confirmed by further studies, medical assessment of baldnesscould possibly be used to help identify men who may be at increased risk ofaggressive prostate cancer. His research team is currently conducting twoadditional cohort analyses exploring the relationship between male patternbaldness and risk of developing and dying from prostate cancer. One of thestudies includes a baseline dermatologic assessment of male pattern baldness,which may be more reliable than the recall method, which was used in thepresent study. This research was supported by the intramural program of theU.S. National Cancer Institute, National Institutes of Health.
庫(kù)克博士認(rèn)為如果這個(gè)發(fā)現(xiàn)被進(jìn)一步的研究所證實(shí)，那么脫發(fā)醫(yī)療審定可用來(lái)幫助識(shí)別患前列腺癌可能性增加的男性。他的研究團(tuán)隊(duì)目前正在實(shí)施兩個(gè)補(bǔ)充的斷代分析，探索男性某種類(lèi)型的脫發(fā)與前列腺癌發(fā)展和惡化之間的聯(lián)系。其中一個(gè)研究包括模式脫發(fā)的頭皮層發(fā)根評(píng)估，這比目前研究中使用的依靠回憶要可靠地多。此研究得到了美國(guó)國(guó)立衛(wèi)生研究院、美國(guó)國(guó)家腫瘤研究所內(nèi)部項(xiàng)目的資助。
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