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經(jīng)濟學人:更年期激素替代療法的利與弊(2)

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And yet the conclusions of the study in 2002 were rapidly debunked. A re-examination of its results showed that women aged between 50 and 59 who took HRT were 31% less likely to die of any cause during their five to seven years of treatment with the hormones than those who did not. For a woman who has had her uterus removed or who starts menopause before the age of 45, HRT greatly reduces the risk of heart disease, a life-saving effect. It can also prevent osteoporosis, a disease in which bones become brittle. One study of postmenopausal American women over a ten-year period found that, of those who had had hysterectomies, between 18,000 and 91,000 died prematurely because they had shunned hormone therapy. HRT also lowers women’s risk of uterine and colon cancers. Fears about the increased risks of breast cancer have been overplayed.

然而,2002年的研究結(jié)論很快就被揭穿了。一項對結(jié)果的重新檢驗表明,在接受激素替代療法的5到7年里,年齡在50到59歲之間的婦女因任何原因死亡的可能性比未接受激素替代療法的婦女低31%。對于子宮切除或45歲前更年期的婦女來說,激素替代療法大大降低了患心臟病的風險,這是一種挽救生命的效果。它還可以預防骨質(zhì)疏松癥,一種骨質(zhì)變脆的疾病。一項對更年期后的美國婦女長達10年的研究發(fā)現(xiàn),在那些做過子宮切除手術(shù)的婦女中,有18000到91000人因為逃避激素治療而過早死亡。激素替代療法還能降低女性患子宮癌和結(jié)腸癌的風險。關(guān)于乳腺癌風險增加的擔憂被夸大了。

Hormone-replacement therapy2.jpg

Hormonal therapies are typically off-patent and inexpensive. In Britain the annual price tag is only £125 ($165); in the United States generic pills are similarly affordable. And the benefits vastly outweigh the costs. Nothing else controls the symptoms of menopause so well, and a heightened risk of any one disease must be weighed against the lowered risks of contracting several others. Hormonal therapies are not appropriate for all menopausal women. For some, the symptoms are insufficiently severe for it to be worthwhile. The treatment might not be suitable for those with liver disease, or a history of blood clots, or breast or ovarian cancer. But for serious symptoms, alternative treatments are worse than taking HRT. Herbal supplements, yoga and faddy diets— to which some turn in the absence of medical help—may alleviate the unpleasantness of menopause but do not offer the long-term health benefits of HRT. Moreover, the symptoms can portend serious health problems in the future. Doctors could usefully prescribe HRT far more widely than they do today.

激素療法通常是非專利的,而且便宜。在英國,一年的標價只有125英鎊(合165美元);在美國,仿制藥也同樣便宜。而且收益遠遠大于成本。沒有什么比這更好地控制更年期癥狀了,任何一種疾病的高風險都必須與其他幾種疾病的低風險相權(quán)衡。激素療法并不適用于所有更年期婦女。對一些人來說,這些癥狀還不夠嚴重,值得一試。這種療法可能不適用于患有肝病、有血栓病史、乳腺癌或卵巢癌的患者。但是對于嚴重的癥狀,其他療法比激素替代療法更糟糕。草藥補品、瑜伽和流行飲食——有些在沒有醫(yī)療幫助的情況下轉(zhuǎn)而采用——可能會減輕更年期的不愉快,但不會提供激素替代療法的長期健康益處。此外,這些癥狀可能預示著未來嚴重的健康問題。醫(yī)生可以比現(xiàn)在更廣泛地使用激素替代療法。

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