lose = failed in winning something.
One more wrong move and we will lose the match.
再錯一步，我們就會失掉比賽。

lose = waste
Do not lose your time on something stupid like video games.
不要浪費你的時間去打游戲。

lose 走神
I lost her when she started talking about thermodynamics.
她一開始跟我講熱力學，我就走神了。

lose one's shit = 讓某人抓狂
Don't make me lose my shit.
別讓我發飆。

lose my cherry = 第一次做某事
Yesterday I lost my cherry playing PUBG.
昨天是我第一次玩吃雞（絕地求生) 。

lose ground to someone or something = 在...領域失去優勢
If you lose your ground in the game, don't lose your head.
如果你在這局游戲里面失去優勢了，別失去理智。

lose one's head = 失去理智
Don't lose your head.
不要失去理智