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新聞周刊:對抗耐藥菌(8)

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The idea of bacteria-proof clothing has so far survived a battery of tests. “We've exposed the treated fabric to all kinds of bacteria over and over again, and we can't find any sticking to it,” she says. “We're still trying to figure out the mechanism, but we know it works with all different types of bacteria.” She has already collaborated with a major medical-supply company to prove that the nanocrystals can be cheaply incorporated into manufacturing processes. Now, she's investigating ways to get the crystals into a variety of other materials used in hospitals, including stainless steel, paint and plastics. These treated materials would stay bacteria-free much longer than conventional hospital surfaces that are wiped with common disinfectants, she says.

到目前為止,防細菌服裝的理念經受住了一系列測試。“我們一次又一次地將處理過的織物暴露在各種細菌中,卻沒有發現任何粘附物,”她表示。“我們仍在試圖找出其機理,但我們知道它適用于所有不同類型的細菌。”她已經與一家大型醫療供應公司合作,證明納米晶體可以廉價地用于制造過程。現在,她正在研究如何將這種晶體植入醫院使用的多種其他材料中,包括不銹鋼、油漆和塑料。她說,與用普通消毒劑擦拭的傳統醫院表面相比,這些經過處理的材料不含細菌的時間要長得多。

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Lasers are another potential weapon against bacteria. Mohamed Seleem, a Purdue University biologist, and his colleagues were trying to come up with a way to quickly identify infectious bacteria in blood samples by hitting the samples with laser light of different colors. Along the way, they noticed that certain drug-resistant bacteria changed color from gold to white just seconds after being hit with a mild beam of blue laser light. Some of these “photobleached” bugs died, and others became so weakened that they lost their resistance to ordinary antibiotics. The blue light, it turned out, damages the pigment in the bacteria's outer membrane. “It only affects a particular pigment,” says Seleem. “So it doesn't harm any other cells.”

激光是另一種對付細菌的潛在武器。普渡大學生物學家穆罕默德塞勒姆和他的同事們正試圖找到一種方法,通過用不同顏色的激光照射血液樣本,快速識別血液樣本中的傳染性細菌。在此過程中,他們注意到某些耐藥細菌在被柔和的藍色激光照射幾秒鐘后,顏色就從金色變成了白色。這些“光漂白”的細菌中,有些已經死亡,而另一些則變得虛弱,以至于對普通抗生素失去了抵抗力。事實證明,藍光會破壞細菌外膜中的色素。“它只影響一種特殊的色素,”薩利姆說道。“所以它不會傷害任何其他細胞。”
Seleem and his collaborators are now working to find ways to tune the color of the laser light to target other resistant bugs. If he succeeds, health care workers would be able to use a laser the size of a flashlight to safely kill dangerous bacteria on patients' skin or disinfect a hospital or doctor's office. It could also be shined on the skin and clothing of health care workers themselves in order to keep them from spreading infections. His collaborators are working to set up clinical trials.
塞勒姆和他的同事們現在正在尋找調整激光顏色的方法,以瞄準其他具有抗藥性的細菌。如果他成功了,醫護人員將能夠使用手電筒大小的激光安全地殺死病人皮膚上的危險細菌,或對醫院或醫生的辦公室進行消毒。它也可以涂在醫護人員自己的皮膚和衣服上,以防止傳播感染。他的合作者正致力于建立臨床試驗。
Seleem also thinks the light could be used on severe, dangerously resistant blood infections, by hooking up a patient to a blood-circulating machine and shining it on the blood as it passes through. “You're basically taking out the patient's blood, sterilizing it and returning it to the patient,” he says.
塞勒姆還認為,通過將病人與血液循環機器連接起來,并在血液通過時將其照射在血液上,這種光可以用于治療嚴重的、具有危險耐藥性的血液感染。“你基本上是把病人的血液取出來,消毒,然后還給病人,”他說。

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重點單詞   查看全部解釋    
clinical ['klinikəl]

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adj. 臨床的

 
fabric ['fæbrik]

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n. 織物,結構,構造
vt. 構筑

 
mechanism ['mekənizəm]

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n. 機制,原理
n. 機械,機構,結構

 
disinfect [.disin'fekt]

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vt. 消毒,殺菌

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variety [və'raiəti]

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n. 多樣,種類,雜耍

 
mild [maild]

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adj. 溫和的,柔和的

 
potential [pə'tenʃəl]

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adj. 可能的,潛在的
n. 潛力,潛能

 
certain ['sə:tn]

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adj. 確定的,必然的,特定的
pron.

 
identify [ai'dentifai]

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vt. 識別,認明,鑒定
vi. 認同,感同身

 
resistant [ri'zistənt]

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adj. 抵抗的,反抗的
n. 抵抗者

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