1.horrible: when someone behaved in a very rude, unkind, or annoying way.
She's a horrible person. 她是個很糟糕的人。
I really don't like her at all. she is horrible. 我真的一點都不喜歡她，她很討厭啊！
be horrible to somebody : 對某個人不友善。
I think I'll just leave if you're going to be horrible to me. 如果你兇我，對我態度不好，我就走！

2.unpleasant: rude or unfriendly in the way you talk to people or answer their questions.
That man in the grocery store is always so unpleasant. 超市的那個人總是很不友善。
be unpleasant to somebody: 對某人態度不好
You shouldn't have been so unpleasant to her. She was only trying to help.你不該對她態度那么不好的，她也只是想要幫忙而已。

3.nasty: someone who is nasty has a very unpleasant character and is often unkind to people.
My first boss was a really nasty person. 我的第一個老板很讓人討厭。
I'd avoid him if I were you. He can be quite nasty. 如果我是你，我就避開他。他很讓人討厭。

4.obnoxious: rude and offensive, especially deliberately.
You're behaving like a spoiled obnoxious child. 你現在就像個被寵壞的沒禮貌的小孩。

5.mean: cruel or not kind.
Don't be so mean to her. 別對她這么刻薄嘛
That's really mean. 這也太過分了吧。

6.creep: someone who you dislike because they are unpleasant and behave in a way that makes you feel uncomfortable.
He didn't say that, did he? What a creep! 天哪他真的這么說了嗎？這人真是討厭！
Get out of here you little creep! You make me sick! 快走開你這個討厭鬼！我看見你就想吐。