評論
打印
Prompt use after infection is vital. Overall, 29% of those receiving REGN-EB3 died.
感染后立即注射是關鍵。整體而言，接受REGN-EB3治療后，29%的患者死亡。
But of people treated when their viral loads were still low, only 6% succumbed.
當那些在病毒量仍然較低時就接受治療的患者，他們的死亡率僅為6%。
For mAb114 the numbers were 34% and 11% respectively—superficially less good,
就mAb114而言，數字分別為34%和11%—表面上看，效果不太好，
but actually indistinguishable statistically from the results for REGN-EB3.
但其實從統計上看，它與REGN-EB3的結果并沒有什么區別。
Two other candidate treatments had significantly worse figures than these, and were therefore rejected by the overseers.
另外兩種候選治療方法的數字明顯更差，因此被監督員拒絕了。
Both REGN-EB3 and mAb114 have histories. Regeneron developed the former in 2016,
REGN-EB3和mAb114都是有歷史記錄的。Regeneron在2016年研發了前者，
in response to an Ebola epidemic in west Africa in which 11,000 people died.
以應對非洲西部的埃博拉疫情，當時該疫情致11000人死亡。
But that outbreak came to an end before the treatment could make its way into clinics,
但在該治療方法進入臨床階段前，該疫情就結束了，
and until this year there had been no opportunity to test it. The story of mAb114 goes back even further.
直到今年才有機會再對其進行測試。mAb114的故事更加久遠。
Its pertinent antibody was isolated from a survivor of an epidemic of Ebola in Congo in 1995.
其相關抗體是從1995年剛果埃博拉疫情幸存者身上隔離出來的。
Both treatments will now be deployed in the field—but, given the smallish size of the trial that approved them,
現在兩種治療方法都將被應用于實地—但由于批準試驗規模較小，
doctors will be looking closely at their relative efficacies to determine whether, in light of more data, one is actually better than the other.
醫生將密切觀察它們的相對效力以根據更多的數據決定哪一個更好。
Regardless of that, effective treatment will surely help break the epidemic directly, by stopping those cured from passing on the virus.
不管如何，有效的治療方法都將通過阻止被治愈者傳播病毒的方式幫助直接阻斷疫情。
It may help indirectly, too. At the moment, those who have become infected,
這也可能起到間接幫助的作用。目前，那些已經被感染的人看到
seeing others go into clinics alive only to leave in coffins, are understandably reluctant to follow suit.
其他人活著走進診所，卻躺在棺材里離開，他們不愿如此，這也是可以理解的。
That means they remain in their homes and spread the illness to others.
這意味著他們仍然待在家中并將疾病傳染給別人。
The prospect of going to a clinic for a cure will change this, and thus also help to break the chain of transmission.
到診所尋求治療的前景將改變這一點，從而也有助于打破傳播鏈。
譯文由可可原創，僅供學習交流使用，未經許可請勿轉載。
