What's wrong with you?/What's the problem?/What's troubling you?

有什么問題嗎？/什么事讓你困擾？

What's on your mind?

你在想什么？

What are you concerned about?

你在擔心什么？

Why the long face?

為什么板著一張臉？

Is everything oK?

一切都還好嗎？

What's going on?/What's up with you?

發(fā)生了什么？

Dialogue1

A: What's wrong with you?

你怎么了？

B: I just lost my job and now I don't know how I'm going to pay my bills.

我剛剛丟了工作，現(xiàn)在不知道該怎么支付我的那些賬單。

Dialogue2

A: You don't look too happy. What's up with you?

你看起來不太開心，你怎么了？

B: I just took my midterm exam and I think I bombed it.

我剛剛參加了期中考試，我覺得我考砸了。

bomb在這里指“不成功”，“失敗”。

A: Hello, Mrs Summers. This is Mrs Li. Mike hasn't come home yet, and I'm getting a little concerned. What time did he leave school?

薩默斯夫人，您好，我是李太太。邁克現(xiàn)在還沒有到家，我有點擔心，請問他是什么時候離開學校的？

B: About an hour ago. But I wouldn't worry too much, you know how boys are.

大約一個小時以前，不過我覺得不用太擔心，你知道男孩子嘛。

A: Yeah, I know. But it usually only takes him thirty minutes to walk home.

是的，我明白，但是他通常只要步行30分鐘就能到家了。

B: Maybe he stopped off at a friend's house.

他可能中途去朋友家了。

A: Yeah. Maybe you're right. Oh, wait, I think I hear the door opening now.

可能是這樣。哦，等一下，我好像聽到開門了。