Down the toilet
浪費(fèi)或失去某物

經(jīng)常與go/went連用
有時(shí)也有一種“可惜”的感覺
好像“某物”掉進(jìn)馬桶沖走了

His whole career went down the toilet because they found out he cheated on his college entrance exams. He'll never work in this industry again.
他整個(gè)職業(yè)生涯都?xì)Я耍驗(yàn)樗麄儼l(fā)現(xiàn)他大學(xué)入學(xué)考試作弊了。他以后永遠(yuǎn)都沒辦法干這行了。

Down the drain
白費(fèi)了，浪費(fèi)了
意思和down the toilet一致
這里drain就是“下水道”

Well, all my money went down the drain because I listened to your investment advice.
我所有的錢都沒了，因?yàn)槲衣犃四愕耐顿Y意見。

Squander
揮霍，浪費(fèi)（金錢，時(shí)間）

You squandered all your savings on a new car. Where will you live?
你把你所有的積蓄都揮霍在這輛新車上了。你以后住哪？

Miss an opportunity
錯(cuò)失機(jī)會(huì)/錯(cuò)失良機(jī)
opportunity of a lifetime
一般指“千載難逢的機(jī)會(huì)”

I've missed the opportunity of a lifetime because I was too worried about failing.
我錯(cuò)過了一個(gè)千載難逢的機(jī)會(huì)，因?yàn)槲姨ε率×恕?br />

Throw it away
扔掉，放棄，付之東流
這個(gè)剛發(fā)一般是“抽象的說法”

You're throwing away your promotion just so you can be with a coworker you like. I think you're making a big mistake.
你為了跟同事談戀愛就放棄了晉升的大好機(jī)會(huì)。我覺得這是個(gè)天大的錯(cuò)誤。

Kiss something goodbye
永遠(yuǎn)失去某物，說拜拜
這里something可以是很多東西
比如：your 6-pack 你的六塊腹肌

If you continue sitting on the couch all day, you'll be kissing your girlfriend goodbye. No girl wants a lazy man.
如果你再繼續(xù)這樣天天坐在沙發(fā)里，你就可以跟你的女朋友永別了。沒有女人喜歡懶男人。