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The pain-relieving effects of drugs like ibuprofen are well known.
像布洛芬這樣的止痛藥物是非常有名的。
But ibuprofen and its relatives, known as nonsteroidal anti-inflammatory drugs, may someday have another use—as antibiotics.
但人們所熟知的布洛芬及其類似的非類固醇抗炎藥物也許某天會作為抗生素用作他途。
Researchers tested three anti-inflammatory drugs: bromfenac, used in eye drops, and carprofen and vedaprofen, both for treating conditions like arthritis in dogs.
研究人員們測試的三種抗炎藥物為用于滴眼液的溴芬酸，用于治療狗類關(guān)節(jié)炎癥的卡洛芬和維達(dá)洛芬。
Investigators found that all three drugs bind to something called the "DNA clamp" in bacteria.
經(jīng)研究調(diào)查人員發(fā)現(xiàn)這三種藥物都能和細(xì)菌中被稱為“DNA 夾”的物質(zhì)進(jìn)行連接。
That clamp is essential to repairing and replicating DNA.
而DNA 夾對于修復(fù)和再造DNA起到關(guān)鍵作用。
By jamming it, the painkillers can actually kill live E.coli—in a test tube, at least.
通過干擾這種連接作用，止痛劑可以有效殺死大腸桿菌埃希式菌，至少在試管中確實(shí)有效。
The findings appear in the journal Chemistry & Biology.
這一研究已在《化學(xué)和生物學(xué)》雜志上發(fā)表。
Study author Aaron Oakley, of Australia's University of Wollongong, says we still need clinical trials to tell if this trick holds true in humans.
該研究的作者澳大利亞伍倫貢大學(xué)的阿倫奧克萊表示仍然需要臨床試驗(yàn)來證明這一方法在人類身上起效。
But this study is a first step.
但這項(xiàng)研究已經(jīng)邁出了第一步。
"I guess it alerts a lot of clinicians to the fact that some of the nonsteroidal anti-inflammatories that they're using may have this off-target effect."
“我想這會為許多醫(yī)師敲響警鐘，那就是一些非類固醇類的抗炎藥物在使用時(shí)也許能會產(chǎn)生脫靶效應(yīng)。”
And it gives drug developers—like Oakley and his colleagues—a whole new way to attack antibiotic-resistant bacteria.
而且它也給奧克萊和他的同事們這樣的藥物研發(fā)人員們提供一種攻克耐抗生素細(xì)菌的全新方式。
